Yes, there are quite a few differences between Swiss High German and German High German. Dialect, unique words and foreign languages flow into Swiss High German

The Germans actually make fun of this. There was a really funny skit by Bully & Rick, where Rick plays a Swiss working in advertising. About every third or fourth word out of his mouth was in English, and at one point Bully's character turns to him and says (in German) "This just does not exist in the German language," when Rick tries to manipulate a verb into a comparative. Was rather funny. Part one: http://www.youtube.com/watch?v=MUp1x_ZLILg

One small comment: I would not say that the differences, though, are *that* significant. You just have to watch out. die Butter (DE) or der Butter (CH)?