Hi,
I am in the same boat as you. Been offered a job, and now my wife is looking for a job in the Vaud / Fribourg area.
The answer depends on the languages and qualifications of your wife.
If your question is about English-speaking companies, there is a separate thread about this:
[Swiss Job market] English-Speaking Companies
If specifically, your wife is looking at multinational companies in the Vaud region, I found the following website a good starting point to learn more about opportunities in the region:
http://www.vd.ch/fr/themes/economie/...ltinationales/
Good luck !