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Old 17.02.2016, 10:50
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Anti-asthma Vaccine for Cats and Dogs

I'm looking for opinions about this product:

http://www.hypopet.ch/catowner

which is currently under development at a spin-off of Zurich Uni. It aims to vaccinate the pet (cat or dog), not the owner, against the protein responsible for causing asthma in humans. It's unclear (to me) what stage of development they have reached, and I'd love to hear others' thoughts about how long it could take for such a drug to become available to pet owners, as well as opinions on potential efficacy of the treatment and its harmlessness to the animal.

Another company is in Phase III development of a treatment for humans who suffer from cat allergy, but of course with theirs it is the person who gets the jab:

http://www.circassia.com/pipeline/product/cat-allergy/

Again, I'd love to hear what others think.
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Old 17.02.2016, 11:12
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Re: Anti-asthma Vaccine for Cats and Dogs

Interesting.

As casual readers of the Pet Corner might surmise my life is all about dogs.

But my beloved niece has managed to fall in love with, and become engaged to, a wonderful gentleman... who happens to be deathly allergic to dogs. So my niece and soon to be nephew-in-law cannot visit us here, which is such a shame. (Na ja, always a good excuse to meet in Paris, but I digress...)

Were my current crew healthy I would be willing to trial this vaccine, in fact - after suitable study of the research and discussions with my vets, due diligence, etc. - I would even say I'd be eager to.

Unfortunately two of the current members of the Muttley Crew are compromised due to health issues, certain vaccines are contraindicated in their cases, and we have to carefully approach many drugs. So I could not risk a new drug with them.

But in the meantime I'll be watching this development with great interest.

Thanks for bringing this up!

---

As an aside, I wish there were more research and development into treating canine CB/asthma/respiratory problems. A 'pet' issue with me, but it seems that this is a speciality where there is need for more academic interest...
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Old 17.02.2016, 11:27
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Re: Anti-asthma Vaccine for Cats and Dogs

Thank you Meloncollie - I value your opinion a lot.

I've been following Circassia for a couple of years but Hypopet's approach of vaccinating the animal appeals to me since it wouldn't require a lengthy course of treatment. It is potentially free of side-effects for both "parties" although I haven't had a vet's opinion about this yet. Here's hoping this thread will draw a response from one!
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Old 17.02.2016, 11:42
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Re: Anti-asthma Vaccine for Cats and Dogs

I would be most interested as to how they intend to produce a vaccine direcetd towards an endogenous protein and how they intend to target it against a protein sysnthesised in a mucosal tissue.

My approach would be to generate a genetically modified cat that doesn't produce Fel d 1, the protein responsible for cat allergies .
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Old 17.02.2016, 12:04
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Re: Anti-asthma Vaccine for Cats and Dogs

Well, they're not giving much away:

"The scientific team has discovered the possibility to reduce the secretion of allergens known to cause allergy and asthma in humans by a simple vaccination of the cat."

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Old 17.02.2016, 12:11
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Re: Anti-asthma Vaccine for Cats and Dogs

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Well, they're not giving much away:

"The scientific team has discovered the possibility to reduce the secretion of allergens known to cause allergy and asthma in humans by a simple vaccination of the cat."

And that is something that worries me. I'd want to see the research and peer reviews, I'd want a heck of a lot of information - and their website doesn't give any.

Now I understand that in the initial stages they might be worried about intellectual property issues... but pet owners will need more than vague statements in order to be willing to become involved.

Also, I'd be interested in learning more about the relationship between Uni ZH and this spin-off - as in, is there an on-going relationship. (Regulatory concerns, bonafides, etc.)
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Old 20.02.2016, 16:02
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Re: Anti-asthma Vaccine for Cats and Dogs

That is exactly it: they are still in the development phase and will no doubt need to raise funds in order to support the process of bringing this to market. Prospective investors will expect IP to be, well, proprietary. The relationship with the Uni sounds good to me since it allows the researchers to use expensive facilities they couldn't acquire themselves and to conduct their work in an academic environment.

Other encouraging signs: they won a first prize from the 2013 Swiss Technology Awards in the "inventions" category, and Gabriela Senti, one of the co-founders, is the head of the Zurich University Hospital clinical trials center.

I certainly hope they succeed! Having to forego the happiness of having a pet because of allergy is...
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