Thread: Coronavirus
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Old 26.01.2021, 19:46
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Re: Coronavirus

A potentially important "breakthrough" by a research institute in TI.

Google EN translation of article from LeMatin (Swiss Romande newspaper) today.

"Ticino discovers a double weapon against the virus

An institute in Bellinzona has developed an antibody that not only protects against all variants of the coronavirus, but also prevents it from mutating. Great hopes are allowed.

This is a great success announced by the Biomedicine Research Institute (IRB) of Bellinzona (TI). The development of a second-generation double antibody, effective not only against all variants of the coronavirus, but which also prevents it from mutating further.

Immunotherapy is a technique that helps fight diseases by injecting the human body, for example, with antibodies. It has already proven itself against the coronavirus, but so far it has faced two major obstacles, the institute, which is affiliated with the University of Italian Switzerland, said in a statement. An antibody could be effective against a strain of the virus, but not necessarily against its variants. And the coronavirus has, like all viruses, a mechanism that allows it to mutate to precisely resist treatments that combat it.

Encouraging preclinical tests

The IRB found the solution by bringing together two natural antibodies (thus produced by the human body) into a single artificial molecule. This bispecific antibody, as it is called, therefore has a dual action, targeting two sites through which the virus infects the human body. According to preclinical tests carried out, it strongly neutralizes the coronavirus, even its recent British variant. And it prevents it from modifying its structure, therefore from mutating.

During these preclinical tests, a single injection of this bispecific antibody was enough to offer instant protection against Covid. It reduces the viral load in the lungs and reduces the inflammation typical of the disease.

The ideal candidate to protect us

For IRB, these promising results make this antibody "an ideal candidate for human clinical trials, with good potential for use" not only to treat the disease but also to prevent catching it. “Despite the limited resources compared to large pharmaceutical companies, we achieved our goals in just a few months,” says Davide Robbiani, IRB director.
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Last edited by Verbier; 26.01.2021 at 20:22. Reason: Added some bolding
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