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  #21  
Old 13.07.2013, 01:48
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Re: HPV Vaccine - Gardasil - for males

Does anyone know why the magic age number is 26?
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  #22  
Old 13.07.2013, 01:57
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Re: HPV Vaccine - Gardasil - for males

My educated guess is that the vast majority of males would have caught HPV by that age (it's sexually transmitted)... so no point immunising older men....
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Old 12.09.2014, 01:20
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Re: HPV Vaccine - Gardasil - for males

I would like to know why 26 as well?
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Old 12.09.2014, 16:56
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Re: HPV Vaccine - Gardasil - for males

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I would like to know why 26 as well?
Snipped from the U.S. CDC site:
"HPV vaccination is not currently recommended for [men or] women over age 26 years. Clinical trials showed that, overall, HPV vaccination offered... limited or no protection against HPV-related diseases. For women over age 26 years, the best way to prevent cervical cancer is to get routine cervical cancer screening, as recommended."

Okay, so if it offers limited or no protection against HPV-related diseases...why get it at any age?
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Old 12.09.2014, 18:12
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Re: HPV Vaccine - Gardasil - for males

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Snipped from the U.S. CDC site:
"HPV vaccination is not currently recommended for [men or] women over age 26 years. Clinical trials showed that, overall, HPV vaccination offered... limited or no protection against HPV-related diseases. For women over age 26 years, the best way to prevent cervical cancer is to get routine cervical cancer screening, as recommended."

Okay, so if it offers limited or no protection against HPV-related diseases...why get it at any age?
In layman's terms getting cancer from HPV is a complicated and circular process. Each time you get an HPV infection you are more likely to get another. It is a bit like shingles - the vaccine is imbeded very deeply in the dermis and sometimes lies dormant. As the infection becomes more "mature" it gets harder for the immune system to pick it up, hence vaccination needs to be before this level of maturity.

Why 26 vs. 24, 25 or 27? I guess for a couple of reasons:
1) because the host will have been exposed too often - on average - to HPV infection for any benefit to be derived from vaccination, thus
2) the cost-benefit ratio is no longer in favour of immunising, and in addition
3) statistically you may be more likely to achieve success with screening than vaccination

These are educated guesses based on the type of reasons these decisions are based from my experience in the pharma industry.

Vaccine success is usually assessed by antibody titers - i.e. the amount of antibody seen post vaccination - there should be a peak. The less exposed someone is to the antigen (the foreign body that causes the reaction) the greater the peak post vaccination. It is possible that in subjects studied these were neglible post age 26, meaning that HPV was no longer registered as a foreign body in these subjects. Again, I've not looked this up, just sharing some of my knowledge on the topic.
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Old 12.09.2014, 18:31
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Re: HPV Vaccine - Gardasil - for males

More simply. HPV is a sexually transmitted virus. The vaccination can prevent infection, but once you have the virus you have it for life.

About 80 percent of adults carry the virus. It causes a large percentage of cervical cancer. Once you have the virus, the only thing to do is for women to have regular pap-smears to check for cancer.

It is assumed that then vast majority of men will have had sexual contact and managed to catch HPV by the time they are 26. There is no point immunizing older adults as they are probably already infected.

The vaccine does nothing once you are infected, it is only useful to prevent the initial infection if they can activate the immune system before you get exposed to the virus. So it does not prevent the subsequent infections/conditions (cervical cancer) caused by the HPV.

I discussed this with my gynaecologist and she agreed that it is now understood that the vast majority of cervical cancer is due to HPV. That means in rough laymans terms you could consider cervical cancer to be a sexually transmitted. Women who have never had sexual contact (with anyone, male or female) and have not managed to pick the virus up another way, are very low risk for cervical cancer.
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Old 13.09.2014, 13:00
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Re: HPV Vaccine - Gardasil - for males

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It is assumed that then vast majority of men will have had sexual contact and managed to catch HPV by the time they are 26. There is no point immunizing older adults as they are probably already infected.
I still think it would be better to test first, then immunise if the person is not infected, even if they are older than 26.
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  #28  
Old 13.09.2014, 13:14
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Re: HPV Vaccine - Gardasil - for males

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I still think it would be better to test first, then immunise if the person is not infected, even if they are older than 26.
There is no HPV test for men. You cannot tell if they are infected or not.
http://www.mayoclinic.org/tests-proc...n/prc-20015066
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  #29  
Old 14.09.2014, 09:21
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Re: HPV Vaccine - Gardasil - for males

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The vaccine does nothing once you are infected, it is only useful to prevent the initial infection if they can activate the immune system before you get exposed to the virus. So it does not prevent the subsequent infections/conditions (cervical cancer) caused by the HPV.
That is not strictly true. What I was trying to explain is that your immune system starts to be de-sensitised to HPV over time after each cycle of infection "flare" if you will. The exact time-frame is not known, but as you point out mid-20s is when the vaccine has no benefit.

That is why vaccination should be done earlier than 12 years, ideally, as this allows the immunity to develop before sexual activity starts (cue to religious fundamentalists up in outrage), but also why they recommend catch-up vaccination in people up to their mid-20s depending on the health authority.
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  #30  
Old 23.09.2014, 23:23
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Re: HPV Vaccine - Gardasil - for males

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Under the freedom of information act, let alone various EMA and FDA edicts, you can demand to see all the data for studies.

Why aren't these people who are worried about vaccination doing so?
I did a quick search for "CBS CDC FOIA" as I heard long time ago about FOIA not being so effective. Found this:

http://www.cbsnews.com/news/freedom-...dc-government/
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Old 29.09.2014, 10:46
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Re: HPV Vaccine - Gardasil - for males

OP, I don't know if you've found a GP yet, but I had my two last Gardasil shots administered here in CH. It was my gynecologist who administered the shots, they had the vaccine ready in the office. I'd already had one shot some years back but moved and never got around to get the last doses. I was in for a routine check and was offered to finish the shots (for those interested, I've had some small cell changes on my cervix, gyno had no doubt I should get the last shots) I got the last two shots for free (was 26 at the time).

Perhaps contact a gynecologist!
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  #32  
Old 12.12.2014, 14:22
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Re: HPV Vaccine - Gardasil - for males

Merck & Co has announce that it now has FDA approval for a new version of Gardasil.

It now covers 9 of the most common viruses vs 4 in the original version. This should now give protection from 90% of the viruses that cause cervical and other related cancers.

The new product name is Gardasil 9.

Link: http://www.huffingtonpost.com/2014/1...n_6308534.html
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Old 12.12.2014, 19:15
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Re: HPV Vaccine - Gardasil - for males

I'd try the travel clinic. My husband walked in there and got all his vaccines right before he went on safari without an appointment. I'm a pediatrician in the US and think it is great you are aiming to get vaccinated . . . if only I could convince more parents of teenage boys HPV wouldn't be so rampant!
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Old 29.01.2015, 01:36
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Re: HPV Vaccine - Gardasil - for males

I wonder if the OP had any success in arranging the Gardasil vaccination. With the increasing evidence linking oropharyngeal cancer with HPV infection of the same types that cause cervical cancer, it seems very likely that men could also benefit from the vaccination. At the moment, more research is needed in this area, but I see it as a "better safe than sorry" thing.
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Old 29.01.2015, 08:02
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Re: HPV Vaccine - Gardasil - for males

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Merck & Co has announce that it now has FDA approval for a new version of Gardasil.

It now covers 9 of the most common viruses vs 4 in the original version. This should now give protection from 90% of the viruses that cause cervical and other related cancers.

The new product name is Gardasil 9.

Link: http://www.huffingtonpost.com/2014/1...n_6308534.html

I should give an update on the Gardasil 9. From what I understand, it is still not approved for use in CH. So any vaccine will be the "old" version that just covers four of the viruses.

You should be able to get the vaccine from any doctor or clinic (they might need to order it so call ahead).
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  #36  
Old 21.10.2016, 10:41
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Re: HPV Vaccine - Gardasil - for males

An update from the CDC in the US.

http://www.huffingtonpost.com/entry/...4f8e9?section=
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Old 21.10.2016, 19:23
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Re: HPV Vaccine - Gardasil - for males

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I should give an update on the Gardasil 9. From what I understand, it is still not approved for use in CH. So any vaccine will be the "old" version that just covers four of the viruses.

You should be able to get the vaccine from any doctor or clinic (they might need to order it so call ahead).
An update. It seems that Gardasil 9 is now APPROVED for use in CH (29.07.2016). It is the one you should have for your children (F/M).

It now covers 9 of the most common viruses vs 4 in the original version. This should now give protection from 90% of the viruses that cause cervical and other related cancers.

Link: https://www.swissmedic.ch/zulassunge...x.html?lang=fr


Girls: Prevention of cervical cancer, vulvar cancer, vaginal carcinoma, premalignant genital lesions and genital warts.

Boys:
Prevention of genital warts caused by HPV 6 and 11. (and of course transmission to girls).
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Last edited by Verbier; 21.10.2016 at 21:29. Reason: Added some info
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  #38  
Old 21.10.2016, 22:38
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Re: HPV Vaccine - Gardasil - for males

From this year, the HPV vaccine is also recommended for boys in Vaud. They offer it for free at public schools in year 9H.

Don't know about other canton though.
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Old 22.10.2016, 12:09
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Re: HPV Vaccine - Gardasil - for males

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From this year, the HPV vaccine is also recommended for boys in Vaud. They offer it for free at public schools in year 9H.

Don't know about other canton though.
Be interesting to know if they are moving up to the Gardasil 9 as part of the program. Hopefully.
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Old 22.10.2016, 13:42
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Re: HPV Vaccine - Gardasil - for males

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Be interesting to know if they are moving up to the Gardasil 9 as part of the program. Hopefully.
I'll ask our school nurse. The first series of vaccination was two weeks ago for 9th graders in the school where I work, so he must surely know. Apparently he was pleasantly surprised at the number of boys whose parents agreed to have them take the HPV vaccine. Far more than he expected for a first year.
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