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  #61  
Old 22.03.2018, 09:07
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Re: Interesting new approach to treating multiple sclerosis (MS)

Another personal story.

http://www.bbc.co.uk/news/resources/...iple_sclerosis
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  #62  
Old 23.10.2018, 11:15
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Re: Interesting new approach to treating multiple sclerosis (MS)

It seems that some CH researchers at the Uni Zurich have come up with a new approach that may help stop/slow down the progression of MS. In a few words it helps retrain the immune system to work properly.

Sorry, the only (non technical) article that I have found is in FR so you will need to use Google if you do not read FR.

Link: https://www.pourquoidocteur.fr/Artic...eoS9nsprVxDf1w
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  #63  
Old 23.10.2018, 11:34
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Re: Interesting new approach to treating multiple sclerosis (MS)

Multiple sclerosis: Swiss researchers discover a revolutionary treatment
By Raphaëlle de Tappie

Swiss researchers have succeeded in developing an effective treatment to combat the progression of multiple sclerosis without any side effects.

This could change the lives of the 2.3 million people with multiple sclerosis around the world. Swiss researchers have succeeded in developing an effective treatment to combat the progression of the disease without any adverse side effects, according to a study published on Wednesday, October 10 in the journal Science Transnational Medicine.

Multiple sclerosis is an autoimmune disease that affects the entire central nervous system and most often appears around the age of 30. A dysfunction of the immune system leads to lesions that then cause motor, sensory and cognitive disturbances. In the more or less long term, these disorders sometimes progress towards an irreversible disability.

For years, scientists have been searching for an infectious cause of this disease that would cause a disruption of the immune system and start attacking myelin sheaths rather than pathogens. But for the first time, Professors Mireia Sospedra and Roland Martin of the University of the Clinical Research Centre for Multiple Sclerosis in Zurich wanted to focus on the immune cells responsible for the disease process.

These react to a protein called GDP-L-fucose synthase, an enzyme formed in a bacterium frequently found in the intestinal flora of patients with multiple sclerosis. "We believe that immune cells are activated in the gut and then migrate to the brain where they cause an inflammatory cascade when they meet the human variant of their target antigen," explains Mireia Sospedra.

A radically different approach to the treatments currently available

She and her colleagues collected blood from a group of volunteers with multiple sclerosis. They then attached fragments of an immunoactive protein to the surface of blood cells in the laboratory. Once the blood was reintroduced into patients' vessels, the fragments helped them to rebuild their immune systems. And, this, without any deplorable side effects, unlike the treatments currently available for multiple sclerosis, the researchers are pleased with. "Our clinical approach specifically targets pathological self-reactive immune cells," notes Mireia Sospedra. This approach is therefore radically different from other treatments that asphyxiate the entire immune system.

Thus, the intestinal microbiota could play a greater role in the pathogenicity of the disease than previously thought, conclude the researchers, who hope, in the long run, to be able to apply their findings to treatment. Because if existing treatments are successful in reducing disease outbreaks, they are struggling to control the progression of the disease. In addition, the side effects are very painful for patients.

Corticosteroids, such as oral prednisone and intravenous methylprednisolone, often prescribed to reduce inflammation and reduce the duration of relapses, tend to cause insomnia, increased blood pressure, increased water retention or osteoporosis. As for the introduction of disease-modifying immunomodulators that reduce the frequency of relapses by 30%, it is known to cause a "flu-like" syndrome that can manifest itself in muscle pain, fever, chills and a feeling of weakness. Skin reactions also occur a few hours after injection during the first three months of treatment. Finally, an attack of the liver (reversible) sometimes occurs but it is generally benign.

Translated with www.DeepL.com/Translator

Looks promising, let's hope further research/testing confirms their findings.
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Old 23.10.2018, 17:56
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Re: Interesting new approach to treating multiple sclerosis (MS)

Not that I was being lazy, but I understood that on EF we were not allowed to "copy" large sections or the 100% of an article.

In any event, thanks for posting it for those who do not read FR. The only EN articles I found were too technical/medical.
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Old 23.10.2018, 18:14
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Re: Interesting new approach to treating multiple sclerosis (MS)

Can't see a problem myself since the article is linked to, but maybe a mod can enlighten me.
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  #66  
Old 23.10.2018, 18:34
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Re: Interesting new approach to treating multiple sclerosis (MS)

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Not that I was being lazy, but I understood that on EF we were not allowed to "copy" large sections or the 100% of an article.

In any event, thanks for posting it for those who do not read FR. The only EN articles I found were too technical/medical.



Some things are important enough that they surpass the rules.....
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  #67  
Old 23.10.2018, 18:56
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Re: Interesting new approach to treating multiple sclerosis (MS)

Here the official press release im German.

https://www.media.uzh.ch/de/medienmi...Darmflora.html

This is fantastic news.
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  #68  
Old 25.10.2018, 08:08
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Re: Interesting new approach to treating multiple sclerosis (MS)

This is an interesting development and perhaps explains why diet and lifestyle intervention programs have shown a lot of promise as a treatment for MS. I'm looking forward to following the developments...
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Old 25.10.2018, 08:10
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Re: Interesting new approach to treating multiple sclerosis (MS)

By the way, here's the official press release in English: https://www.media.uzh.ch/en/Press-Re...Darmflora.html
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Old 09.05.2019, 10:51
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Re: Interesting new approach to treating multiple sclerosis (MS)

Hopefully this will be available in Switzerland too.

"Ocrelizumab is the first and only licensed treatment for primary progressive MS in Europe."

https://www.bbc.com/news/health-48191442
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Old 09.05.2019, 11:21
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Re: Interesting new approach to treating multiple sclerosis (MS)

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Hopefully this will be available in Switzerland too.

"Ocrelizumab is the first and only licensed treatment for primary progressive MS in Europe."

https://www.bbc.com/news/health-48191442
It's already licensed in Switzerland and available to patients.
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  #72  
Old 09.05.2019, 11:28
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Re: Interesting new approach to treating multiple sclerosis (MS)

Oh that's great news for people who suffer from this form of MS.
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Old 08.10.2019, 18:32
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Re: Interesting new approach to treating multiple sclerosis (MS)

Some more interesting research being done to help repair the damage done by MS.

"We have to look at ways to stop the nerves dying," she says. "We want to be able to try to limit that either by keeping the nerves alive, or keeping them working better."

Repurposing existing drugs to help with remyelination should prove the quickest route to therapies for progressive forms of MS, because creating and licensing new ones is a much lengthier and more expensive process.

Prof Williams still sees patients at the Anne Rowling Clinic of Regenerative Neurology in Edinburgh, named in memory of the Harry Potter author J K Rowling's mother, who had MS. (The author this year donated £15m for research at the unit.)

"At the moment, with PPMS or SPMS, we can always give relief for pain or stiffness but we won't change the course of the disease.

"So for those patients, to slow or stop or reverse the disease can only be done with more research, and money is critical for research."

The biggest trial yet in the UK for patients with secondary progressive MS is the MS STAT2 trial, conducted by Prof Jeremy Chataway for the UCL Queen Square Institute of Neurology in London.

The trial is still recruiting at 30 centres across the UK to look at whether simvastatin, a drug used to treat high cholesterol, can slow or stop disability progression. If so, it has the potential to become one of the first disease-modifying therapies for people with secondary progressive MS.

And perhaps most encouraging of all, Prof Robin Franklin and his team at the Wellcome-MRC Cambridge Stem Cell Institute recently published research suggesting a common diabetes drug - metformin - could hold the key to stopping disease progression in MS.

Costing just a few pence per tablet, metformin appears to have an ability to restore cells to a younger, healthier state and encourage myelin regrowth.

The next question is whether it works in people as well as it does in the lab.

Prof Franklin says: "This is a drug that's well tolerated and widely available. There is every reason to believe that the effects that we have seen - which have been so spectacular - will translate into humans.

"This is the great frontier of MS therapy. We're good at stopping the inflammation in MS. What we're not so good at doing is repairing the damage. All this work has given us some real hope that this medicine will reverse the damage done by MS."

https://www.bbc.com/news/health-49935393

Perhaps they should look at people who have both diabetes and MS and take Metformin and study how the disease progresses (or not).
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Old 09.10.2019, 22:51
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Re: Interesting new approach to treating multiple sclerosis (MS)

"Corticosteroids, such as oral prednisone and intravenous methylprednisolone, often prescribed to reduce inflammation and reduce the duration of relapses, tend to cause insomnia, increased blood pressure, increased water retention or osteoporosis"


When I had cancer 13 years ago, I had to take Prednisone for 3 days prior to every chemo cycle. It is an awful drug, like being on speed and you can't stop and sit down. I used to clean my house from top to bottom on it and I'd be ironing at 3 am with the insomnia. The come down the day after the dosage stopped was hell, I'd be in bed for 3 days.



Worst bit was I'd try to listen to relaxation or calm music through headphones to try and help me sleep, but my brain would override it by saying "go on, you really want The Stranglers or The Clash and you want it really LOUD".


I also had to take one called Dexamethosone which makes you crave sweet things and leaves a lot of patients with Type 2
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