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Old 09.11.2011, 22:54
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Re: Swiss doc boycotts Novartis over job cuts

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I'm guessing I've incensed some pharma workers. And I didn't mean to "mislead", although some patients are sensitive to certain fillers in generics. And OK, so maybe it's splitting hairs, but I'm not saying that most generics aren't good enough
Don't get me wrong, I'm not defending generics. I've always worked for innovator drug companies and so generics are a thorn in our side however I wouldn't want to unfairly malign them with innuendo or pseudo science. The whole concept of generic medicines are that a patient can expect the same efficacy and safety from a generic product as they would the originator, and this is what the health authority assess before granting a generic compound a licence. The study you quote above is interesting, as it does show that the margin for similarity may be wide enough that a patient swapping from one to another, may lead to differences in efficacy/safety. However the study is based on modelling and simulation, as opposed to real clinical trial data. A general rule of thumb is that if a doctor places a patient on a particular drug, the patient should stay on that brand (originator or generic) and not keep changing between them.
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Old 09.11.2011, 23:26
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Don't get me wrong, I'm not defending generics. I've always worked for innovator drug companies and so generics are a thorn in our side however I wouldn't want to unfairly malign them with innuendo or pseudo science. The whole concept of generic medicines are that a patient can expect the same efficacy and safety from a generic product as they would the originator, and this is what the health authority assess before granting a generic compound a licence. The study you quote above is interesting, as it does show that the margin for similarity may be wide enough that a patient swapping from one to another, may lead to differences in efficacy/safety. However the study is based on modelling and simulation, as opposed to real clinical trial data. A general rule of thumb is that if a doctor places a patient on a particular drug, the patient should stay on that brand (originator or generic) and not keep changing between them.
I don't consider patient or provider experiences to be innuendo. Nevertheless, for the vast majority of patients generics are fine. In the US, if your doc writes on a script that generics are permitted, then the pharmacy will provide the generic based on what they have. I was on omeprazole for a while and the manufacturer of the capsule changed several times. Not a problem with this drug for me.
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